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Applications: Expression of human TNFR2 in cells of interest.Generate stable cell lines expressing human TNFR2 (puromycin resistant).
Background: Tumor Necrosis Factor Receptor 2 (TNFR2, also known as TNR1B, TNFRSF1B, or CD120b) is a transmembrane receptor of the TNF protein superfamily that binds the pleiotropic pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). TNFR2 can be found in several T-Cell subsets such as regulatory CD8+ T-Cells (Tregs) and CD4+ tumor infiltrating T cells, myeloid lineage cells and some cancer types, and it is involved in autoimmune diseases, graft versus host disease and cancer. It has become an attractive target for cancer immunotherapy, where its different functions as oncogene and immune regulator are being explored. TNFR2 also exhibits neuroprotective properties and promotes tissue regeneration, making it a promising potential therapeutic target for the treatment of Alzheimer 's disease.
Description: The TNFR2 (Tumor Necrosis Factor Receptor 2, or TNR1B) Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles ready to transduce almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce cells with Human TNFR2 (NM_001066.3) driven by a CMV promoter. The lentiviruses also transduce a puromycin selection gene.
Formulation: The lentivirus particles were produced in HEK293T cells in medium containing 90% DMEM + 10% FBS. Virus particles can be packaged in custom formulations by special request, for an additional fee.
Storage Stability: Lentiviruses are shipped with dry ice. For long-term storage, it is recommended to store the lentiviruses at -80°C.
Supplied As: Two vials (500 µl x 2) of lentivirus at a titer≥107 TU/ml. The titer will vary with each lot; the exact value is provided with each shipment.
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-2
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