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Encompassing Amino Acids: TPM3: 1-258, TRKA: 399-end
Applications: Kinase Assay
Background: TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family which is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TRKA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermoregulation via sweating in humans. The oncogenic rearrangement of 5'-TPM3-3'-NTRK1 fusion gene has been found in papillary thyroid carcinomas.
Description: Human TPM3-TRKA fusion protein, TPM3 GenBank Accession No. NM_152263, a.a. 1-258, TRKA Genbank Accession No. NM_002529, a.a. 399-end, expressed in an E. coli expression system. TMP3-TRKA MW = 105 kDa.
Format: Aqueous buffer solution
Formulation: 50 mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Genbank: TPM3: NM_152263, TRKA: NM_002529
Storage Stability: Store product at -80°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Tags: N-Terminal GST-Tag
Uniprot: TRKA P04629; TPM3 P06753
Biosafety Level: Not applicable (BSL-1)
References: 1. Smeyne, R. J. et.al: Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368: 246-249, 1994. 2. Marta G. B. et.al: A Sequence Analysis of the Genomic Regions Involved in the Rearrangements between TPM3 and NTRK1 Genes Producing TRK Oncogenes in Papillary Thyroid Carcinomas. Genomics, Volume 28, Issue 1, 1 July 1995, Pages 15-24
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