Abbreviation: TPX2
Target Synonym: DIL2;p100;DIL-2;HCTP4;FLS353;HCA519;REPP86;C20orf1;C20orf2;GD:C20orf1;TPX2
Conjugation: Unconjugated
UNIProt ID: Q9ULW0
Background: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human TPX2
Dilution: WB 1:500-1:2000,IHC 1:50-1:200,IF 1:50-1:200
English
Deutsch
