Product Type: Inhibitor
CAS No.: 53902-12-8
MolecularFormula: C18H17NO5
Molecular Weight: 327,33
Source: Synthetic
Purity: ≥95% (HPLC)
Solubility: Soluble in DMSO.
Appearance: Off-white to yellow powder.
PubChem CID: 5282230
Scientific Background: Tranilast is an antiallergic, antifibrotic drug that inhibits collagen synthesis, when administered in a dose –dependent manner for a 48 h treatment (1). As an antifibrotic agent, studies shown an effect on the growth of metastasis of mammary carcinoma. It is associated with the inhibition of the growth factor –beta. (TGF-beta) (2).
References: 1. Yamada H., Tajima S., Nishikawa T., Murad S., and Pinnell S., (1999) The Journal of Biochemistrystry. 116(4): 892-897.2. Chakrabarti R., Subramanian V., Abadalla J., Jothy S., Predhomme GJ. (2009) Anticancer Drugs. 20(5): 334-45.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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