Formulation: A solid
Formal Name: 3-(1H-indol-3-yl)-2E-propenoic acid
Purity: ≥98%
Formula Markup: C11H9NO2
Formula Weight: 187,2
Shelf life (days): 1460
CAS Number: 29953-71-7
Notes: trans-Indole-3-acrylic acid is a metabolite of the essential amino acid L-tryptophan (Item No. 29600).{67762} It is formed from tryptophan by gut microbiota. trans-Indole-3-acrylic acid (100 µM) increases the levels of mRNA encoding mucin 2 and Il-10, as well as decreases mRNA encoding Tnf-α, in primary mouse large intestinal spheroids co-cultured with LPS-stimulated primary mouse bone marrow-derived macrophages (BMDMs). It has been used as a precursor in the synthesis of anticancer agents and tubulin polymerization inhibitors, as well as used as a reactive chromophore probe to assess the α and β subunit conformational changes of S. typhimurium tryptophan synthase in tryptophan biosynthesis.{67763,67764}
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