Target: TRAP1
Conjugate: Biotin
Product Type: Monoclonal
Clone Number: 3H4-2H6
Immunogen: Purified recombinant Human TRAP8
Swiss-Prot: Q12931
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~75kDa.
Cellular Localization: Mitochondrion
Scientific Background: The 90 kDa heat shock protein (HSP90) family of proteins that play an important physiological role. HSP90 is involved in numerous cellular processes but is best known for its association with signal transduction machinery. A recently cloned homolog of HSP90 is the tumor necrosis factor receptor-associated protein (TRAP1). Like HSP90, TRAP1 is found to be associated with numerous proteins involved in diverse actions (1, 2). Immunofluorescence data has shown TRAP1 to be localized in the mitochondria of mammalian cells. This observation and the fact that TRAP1 is shown to have a mitochondrial targeting pre-sequence strongly implicates TRAP1 as a mitochondrial matrix protein (3).
References: 1. Felts S.J., et al. (2000) J Biol Chem. 275(5): 3305-3312.2. Costantino E., et al. (2009) Cancer Lett. 279(1): 39-46.3. Cechetto J.D., Gupta R.S. (2000) Exp Cell Res. 260(1): 30-39.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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