Formulation: A solid
Formal Name: N-[2-(4-morpholinyl)ethyl]-N′-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-urea
Purity: ≥95%
Formula Markup: C25H31N5O4
Formula Weight: 465,5
Shelf life (days): 1460
CAS Number: 867164-40-7
Notes: TRC051384 is an inducer of heat shock protein 70 (HSP70) expression.{65588} It increases HSP70 mRNA in HeLa cells and primary rat neurons when used at concentrations of 6.3 and 12.5 µM and activates the transcription factor heat shock factor 1 (Hsf1) in a reporter assay using HeLa cells at 25 µM. TRC051384 (1 µM) reduces apoptosis, decreases the levels of malondialdehyde (MDA), and prevents a decrease in the mitochondrial membrane potential induced by tert-butyl hydroperoxide in isolated human nucleus pulposus stem cells (NPSCs).{65589} Intraperitoneal administration of TRC051384 reduces penumbral incorporation into initial lesions, increases the percentage of animals surviving, and lowers neurological deficit scores in a rat model of cerebral ischemia.{65588}
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