Formulation: A solid
Formal Name: 6-docosanoate 6-O-(1-oxodocosyl)-α-D-glucopyranosyl α-D-glucopyranoside
Purity: ≥95%
Formula Markup: C56H106O13
Formula Weight: 987,4
Shelf life (days): 1460
CAS Number: 66758-35-8
Notes: Trehalose 6,6'-dibehenate (TDB) is a synthetic glycolipid and derivative of trehalose-6,6′ dimycolate (TDM), also known as mycobacterial cord factor.{68365} It binds to a fusion protein of mouse macrophage-inducible C-type lectin (Mincle) and human IgG1 Fc in a cell-free assay when used at a concentration of 10 µg/ml. TDB (5 µg/ml) induces nitric oxide (NO) and G-CSF production in mouse bone marrow macrophages in a Mincle-dependent manner. Liposomes containing TDB and dimethyldioctadecylammonium (DDA; Item No. 26120) as adjuvants and the mycobacterial lipid antigens diacylated sulfoglycolipid (Ac2SGL) and phosphatidyl-myo-inositol dimannoside (PIM2) decrease spleen bacterial load and the number of lung and spleen lesions in a guinea pig model of M. tuberculosis infection.{36983}
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