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Applications: Screen for inhibitors of NGF/TrkA signaling in a cellular context Screen for inhibitors of TrkA kinase activity in a cellular context
Background: A chronic pain mediator, NGF (Nerve Growth Factor) binds to TrkA resulting in activation of the downstream signaling pathway linked to pro-nociception; therefore, targeting the kinase activity of TrkA and the interaction between NGF/TrkA have been attractive tools in pain management research. In addition to control of chronic pain, a recent clinical success has proven that inhibition of TrkA kinase would be a promising anti-cancer strategy.
Description: Recombinant HEK-293 cells expressing firefly luciferase gene under the control of Serum Response Elements (SRE) with constitutive expression of human TrkA (Tropomyosin receptor kinase A; NTRK1; ref. seq. NM_002529.3).
Genbank: NM_002529.3
Host Cell Line: HEK293
Mycoplasma Testing: The cell line has been screened using the MycoAlert™ Mycoplasma Detection kit (Lonza, #LT07-218) to confirm the absence of Mycoplasma species.
Storage Stability: Immediately upon receipt, store in liquid nitrogen.
Supplied As: Each vial contains 2 x 10^6 cells in 1 ml of 10% DMSO in FBS
Biosafety Level: BSL-2
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