Conjugation: HRP: Horseradish Peroxidase
Description of Target: TRPC3 is thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. TRPC3 is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. TRPC3 may also be activated by internal calcium store depletion.
Immunogen: The immunogen is a synthetic peptide directed towards the n terminal region of human TRPC3
Key Reference: Lof,C., (2008) J. Cell. Physiol. 216 (1), 245-252
Molecular Weight: 97kDa
Peptide Sequence: Synthetic peptide located within the following region:
MEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: Short transient receptor potential channel 3
Protein Size: 848
Purification: Affinity Purified
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