TRPC6-PAM-C20, CAS 667427-75-0

Product Description: TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca2+ concentrations ([Ca2+]i) in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals[1].

Applications: Neuroscience-Neuromodulation

Formula: C22H21NO4

References: [1]S Häfner, et al. Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels. Cell Calcium. 2019 Mar;78:26-34.

CAS Number: 667427-75-0

Molecular Weight: 363.41

Compound Purity: 99.78

Research Area: Neurological Disease

Solubility: DMSO : 33.33 mg/mL (ultrasonic)

Target: TRP Channel

• SKU: MEXHY-136190-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-136190-1
• Package Unit: 1 mg
• Quantity Unit: STK