Target: TRPC7
Conjugate: ATTO 488
Product Type: Monoclonal
Clone Number: N64A/36 (Formerly sold as S64A-36)
Immunogen: Synthetic peptide amino acids 845-862 of human TRPC7
Swiss-Prot: Q9HCX4
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~100kDa.
Cellular Localization: Membrane
Scientific Background: Transient receptor potential cation channel, subfamily C, member 7, also known as TRPC7, is a non-selective cation channel that is directly activated by DAG. TrpC7 shows constitutive activity and susceptibility to negative regulation by extracellular Ca2+. Because of this, TrpC7 plays an important role in the Ca2+ signaling pathway (1). TrpC7 is also expressed abundantly in the heart, and combined with its ability to act as a Ca2+ channel, TrpC7 might contribute to the process of heart failure (2).
References: 1. Numaga T., Wakamori M., and Mori Y. (2007) Handb Exp Pharmacol. 179: 143-151.2. Satoh S., et al. (2007) Mol Cell Biochem. 294(1-2): 205-215.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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