Target: TRPM7
Conjugate: FITC
Product Type: Monoclonal
Clone Number: S74
Immunogen: Fusion protein amino acids 1817-1863 (C- terminus) of mouse TrpM7
Swiss-Prot: Q923J1
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~220kDa in extracts of cells transiently transfected with TrpM7. No cross-reactivity against TrpM6.
Cellular Localization: Membrane
Scientific Background: TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants (1, 2).
References: 1. Brauchi S., Krapivinsky G., Krapivinsky L., Clapham D.E. (2008) Proc Natl Acad Sci USA. 105(24): 8304-8308.2. Numata T, Okada Y. (2008) J Biol Chem. 283(22): 15097-15103.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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