Target: TRPV3
Conjugate: Biotin
Product Type: Monoclonal
Clone Number: N15/4 (Formerly sold as S15-4)
Immunogen: Synthetic peptide amino acids 774-791 (C-terminus) of rat TrpV3
Swiss-Prot: Q4QYD9
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~70kDa.
Cellular Localization: Membrane
Scientific Background: The TRPV3 protein belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. The gene lies in close proximity to another family member (TRPV1) gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels (1, 2).
References: 1. Masamoto Y., Kawabata F., Fushiki T. (2009) Biosci. Biotechnol. Biochem. 73(5): 1021-1027.2. Xiao R., et al. (2008) J Biol Chem. 283(10): 6162-6174.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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