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Applications: Studying enzyme kinetics.Screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.
Description: TTK, also known as Monopolar Spindle 1 Kinase (MPS-1), is a dual specific kinase (tyrosine and serine/threonine) that plays an important role in the cell division cycle by regulating spindle assembly checkpoint during mitosis. Recent studies showed that inhibition of TTK induces aberrant mitosis and apoptosis in various cancer cells, suggesting that TTK is a potential cancer therapeutic target. The TTK Kinase Assay Kit is designed to measure TTK kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
Supplied As: The TTK Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant TTK enzyme, MBP substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
Uniprot: P33981
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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