Product Type: Inducer
CAS No.: 11089-65-9
MolecularFormula: C39H64N4O16
Molecular Weight: 844,95
Source: Isolated from Streptomyces lysosuperficus
Purity: >98% (HPLC) as a mixture of tunicamycin A, B, C and D
Solubility: Soluble in DMSO (>10 mg/ml) or ethanol (5 mg/ml; warm).
Appearance: White solid.
Scientific Background: As a nucleoside antibiotic, Tunicamycin blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. This causes an induction of glucose-regulated protein 78 (GRP78) mRNA expression, which in turn increases ER stress and subsequently induces autophagy.
References: 1. Unal E.S., et al. (2008) Biochim Biophys Acta. 1778(6): 1407-14.2. Ding W.X., et al. (2007) J Biol Chem. 282(7): 4702-10.3. Ishii S., et al. (1987) J Neurochem. 49(5): 1606-12.4. Zhang J., et al. (2013) J Surg Res. 183(2): 929-35.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.