Abbreviation: TYK2
Target Synonym: TYK2;IMD35;JTK1
Conjugation: Unconjugated
UNIProt ID: P29597
Background: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human TYK2
Dilution: WB 1:500-1:2000,IF 1:50-1:200