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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Description: TYRO3 is a member of the TAM receptor kinases and plays an important role in cell proliferation/survival, adhesion/migration, and regulation of inflammatory cytokine release. Along with other members of this family, Axl and c-Mer (MERTK), TYRO3 is part of an emerging class of innate immune checkpoints participating in anti-tumoral immunity. Thus, it has been suggested that TYRO3 inhibition could be a promising immunotherapeutic approach in cancer treatment. The TYRO3 Assay Kit is designed to measure TYRO3 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Storage Stability: Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.
Supplied As: The TYRO3 Assay Kit comes in a convenient 96-well format, with enough purified recombinant TYRO3 enzyme, TYRO3 substrate peptide, ATP and kinase assay buffer for 100 enzyme reactions.
Uniprot: Q06418
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: Akalu, Y.T., et al. Immunological Reviews 276:165-177 (2017)
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