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Description: This antibody reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-Related Protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Conjugate: Purified, BSA-free
Concentration: 1 mg/mL
Storage buffer: PBS, no BSA, no azide
Product Origin: Animal - Oryctolagus cuniculus (domestic rabbit)
Clone: TYRP1/2340R
Entrez Gene ID: 7306
Immunogen: Recombinant fragment of human TYRP1 protein (around aa 257-377) (exact sequence is proprietary)
Verified AB Applications: IHC (FFPE) (verified)
Z-Antibody Applications: IHC, FFPE (verified)
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