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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Description: UBE1 dysregulation has been linked to muscular atrophy, tumors, and cancer. The UBE1 Inhibitor Screening Assay Kit is designed to measure UBE1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Supplied As: The UBE1 Inhibitor Screening Assay Kit comes in a convenient 96-well format, with enough purified recombinant UBE1 enzyme, Ubiquitin, ATP, and kinase assay buffer for 96 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Ramser, J., et al. 2008. "Rare missense and synonymous variants in UBE1 are associated with X-linked infantile spinal muscular atrophy." Amer. J.Human Genetics 82(1): 188-193.
2. Leidecker, O., et al. 2012. "The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions." Cell Cycle 11(6): 1142-1150.
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