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Applications: Useful for the study of IDO1, IDO2, and TDO enzymology, screening inhibitors, and selectivity profiling.
Background: L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis in mammalian cells and the L-Trp to kynurenine (Kyn) pathway is firmly established as a key regulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an immunosuppressive microenvironment by starving immune cells of L-Trp and releasing degradation products of L-Trp that have immunosuppressive functions. Indoleamine 2,3-dioxygenases (IDO1 & IDO2) and Tryptophan 2,3 dioxygenase (TDO) are upregulated in many tumors, providing cancer cells with an avenue for immune evasion.
Contraindications: DMSO >0.5%, strong acids or bases, ionic detergents, and high salt.
Description: The Universal IDO1/IDO2/TDO Inhibitor Screening Assay Kit is designed to measure IDO1, IDO2 and TDO enzyme inhibition.
Storage Stability: At least one year from date of receipt when stored as directed.
Supplied As: The kit comes in a convenient format with enough reaction solution and enzyme to perform a total of 50 reactions with each enzyme.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Liu, X., et al., Blood. 2010; 115(17): 3520-3530.2. Seegers, N., et al. J Biomol Screen. 2014; 19(9): 1266-74.
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