Product Type: Inducer
CAS No.: 1143-70-0
MolecularFormula: C13H8O4
Molecular Weight: 228,2
Source: Synthetic
Purity: >98% (HPLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (50 mg/ml)
Appearance: Pale-yellow powder
PubChem CID: 5488186
Scientific Background: Urolithin A (UA) is a microbial metabolite of dietary ellagitannins produced in the gut (1). It has been shown to induce mitophagy and prolong lifespan in C. elegans and increase muscle function in rodents (2). It promotes mitophagy and suppresses NLRP3 inflammasome activation in LPS-induced BV2 microglial cells and in an MPTP-induced Parkinson’s disease model (3). The pro-mitophagy activity of Urolitin A may be beneficial in Alzheimer’s disease (4). Ex vivo UA-treated T cells display improved anti-tumor function (5).
References: 1.Gonzalez-Barrio R., et al. (2011) J. Agric. Food. Chem. 59:11522.Ryu D., et al. 2016 Nat. Med. 22:8793.Qiu J., et al. 2022 Neuropharmacology 207:1089634.Jayatunga D.P.W., et al. 2021 Nutrients. 13:37445.Denk D., et al. 2022 Immunity. 55:2059
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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