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Encompassing Amino Acids: 181-712
Applications: This enzyme is active in the Ub-CHOP assay.
Background: USP33 was originally identified as a protein that interacts with the E3 ubiquitin ligase pVHL, a region commonly mutated in patients with pVHL disease and has been shown to be ubiquitylated by the pVHL E3 ligase complex in vitro and in transiently transfected COS-7 cells. The USP33 catalytic core spans amino acids 181-712.
Description: Human USP33 Core Domain recombinant protein (Genbank Accession No. Q8TEY7), a.a. 181-712, with N-terminal SUMO- and His-tags, expressed in E. coli.
Format: Aqueous buffer solution
Formulation: 25 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM DTT, 10% glycerol
Genbank: Q8TEY7
Storage Stability: Store at or below -80°C. Stable as supplied for up to 1 year when stored dessicated at -80°C.
Tags: N-terminal SUMO-His-tags
Uniprot: Q8TEY7
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. De Pitta, C., et al. A leukemia-enriched cDNA microarray platform identifies new transcripts with relevance to the biology of pediatric acute lymphoblastic leukemia. Haematologica 90(7): p. 890-8 (2005).
2. Li, Z., et al., Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 277(7): p. 4656-4662 (2002).
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