USP5-IN-1, CAS 2851040-81-6

Product Description: USP5-IN-1 (compound 64), a potent deubiquitinase USP5 inhibitor, binds to the USP5 ZnF-UBD with a KD of 2.8 μM. USP5-IN-1 is selective over nine proteins containing structurally similar ZnF-UBD domains. USP5-IN-1 inhibits the USP5 catalytic cleavage of a di-ubiquitin substrate[1].

Applications: Cancer-programmed cell death

Formula: C19H20ClN3O5S

References: [1]Mann MK, et al. Structure-Activity Relationship of USP5 Inhibitors [published correction appears in J Med Chem. 2022 Jan 13;65(1):889]. J Med Chem. 2021;64(20):15017-15036.

CAS Number: 2851040-81-6

Molecular Weight: 437.90

Compound Purity: 99.73

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: Deubiquitinase

• SKU: MEXHY-139979-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-139979-25
• Package Unit: 25 mg
• Quantity Unit: STK