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Applications: Great for studying enzyme kinetics and HTS applications.
Background: Deubiquitinases (DUBs) play important roles in pathways that are dysregulated in cancer, such as DNA repair, cell growth, and apoptosis. This makes DUBs attractive potential drug targets for many cancers and neurodegenerative diseases. Ubiquitin-specific-processing proteases (USPs) are the largest class of DUBs. USP7, also known as herpesvirus-associated ubiquitin-specific protease (HAUSP), acts as a tumor suppressor by stabilizing p53 tumor suppressor as well as a regulator of gene expression in herpes simplex virus (HSV) and Epstein-Barr virus (EBV) infections.
Contraindications: DMSO >1%, strong acids or bases, ionic detergents, high salt
Description: The USP7 Inhibitor Screening Assay Kit is designed to measure USP7 activity for screening and profiling applications. The USP7 Inhibitor Screening Assay Kit comes in a convenient format, with a 96-well plate, fluorogenic, ubiquitinated substrate, assay buffer, and purified USP7 enzyme for 96 enzyme reactions. USP7 is incubated with a sample containing assay buffer and Ub-AMC Substrate, and then the plate is read, measuring fluorescence using a fluorescence reader.
Storage Stability: Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.
Supplied As: The USP7 Inhibitor Screening Assay Kit comes in a convenient format, with a 96-well plate, fluorogenic, ubiquitinated substrate, assay buffer, and purified USP7 enzyme for 96 enzyme reactions.
Uniprot: Q93009
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1.Pfoh, R., et al. Deubiquitinases and the new therapeutic opportunities offered to cancer. Endocrine-Related Cancer. 2015;22(1):T35-T54.
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