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Encompassing Amino Acids: 20-764
Application: Useful for the SDS-PAGE and avidin-binding assays.
Background: The interaction between VEGF (Vascular Endothelial Growth Factor) and its receptor VEGFR is an important mediator of angiogenesis as well as endothelial cell survival and proliferation. VEGFR2 is a receptor tyrosine kinase that plays a major role in cellular responses driven by VEGF. Targeting the kinase activity of VEGFR2 has been an attractive tool in cancer therapy based on its anti-angiogenesis effects. In addition to the kinase inhibitors, humanized monoclonal antibodies interfering with VEGF/VEGFR2 interaction have been developed as anti-cancer treatments.
Description: Recombinant human VEFGR2 (vascular endothelial growth factor receptor 2), also known as kinase insert domain receptor (KDR), encompassing amino acids 20-764 corresponding to the extracellular domain of the receptor. This construct contains a C-terminal Avi-Tag™ followed by an His-tag (6xHis). This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_002253.4
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal Avi-Tag™, His-Tag
Uniprot: P35968
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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