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Encompassing Amino Acids: 20-764
Application: Useful for studying the binding and neutralizing of VEGFR2 in ELISA and cellular assays.
Background: VEGFR2 (Vascular endothelial growth factor receptor 2), also known as KDR (Kinase insert Domain receptor), is a tyrosine kinase receptor for the growth factor VEGF. EGFR (epidermal growth factor receptor) overexpression is a common feature in many cancer types, such as breast and ovarian cancer. EGFR activation results in VEGF expression and signaling via VEGFR2, promoting angiogenesis and tumor progression. The inhibition of VEGFR2 via small molecules or antibodies, alone or in combination with inhibitors of EGFR, are promising therapeutic strategies for cancer therapy.
Description: Recombinant human VEGFR2 (Vascular endothelial growth factor receptor 2), also known as KDR (Kinase insert Domain receptor), encompassing amino acids 20-764(end). This construct contains a C-terminal IgG1 Fc domain, followed by an Avi-Tag™. This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_002253.4
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal Fc-Avi-Tag
Uniprot: P35968
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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