Target: VGLUT2
Conjugate: RPE
Product Type: Monoclonal
Clone Number: N29/29 (Formerly sold as S29-29)
Immunogen: Fusion protein amino acids 501-582 (cytoplasmic C-terminus) of rat VGlut2
Swiss-Prot: Q9JI12
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~60kDa.
Cellular Localization: Cytoplasmic Vesicle,Secretory Vesicle,Synaptic Vesicle Membrane,Membrane,Cell Junction,Synapse
Scientific Background: The ATP-dependent, chloride-sensitive vesicular glutamate transporters (VGLUT) include BNPI (VGLUT1), VGLUT2 (DNPI) and VGLUT3. The brain expresses BNPI (brain specific Na+-dependent inorganic phosphate (Pi) cotransporter) and VGLUT2 in a complementary fashion. The telencephalic regions express BNPI, whereas the lower brainstem and diencephalic regions express VLGUT2. Rat pinealocytes express both BNPI and VGLUT2. The striatum, hippocampus, cerebral cortex and raphe nuclei express VGLUT3 in a small number of neurons. Pancreatic α and β cells express BNPI and VGLUT2 in response to glucose concentrations. Human VGLUT3 shares a 72% sequence homology with VLGUT2 and BNPI.
References: 1. Aihara Y., et al. (2000) J Neurochem. 74: 2622-2625.2. Kaneko T., and Fujiyama F. (2002) Neurosci Res. 42: 243-250.3. Gras C., et al. (2002) J Neurosci. 22: 5442-5451.4. Takamori S., Malherbe P., Broger C., and Jahn R. (2002) EMBO Rep. 3: 798-803.5. Morimoto R., Hayashi M., Yatsushiro S., Otsuka M., Yamamoto A., and Moriyama Y. (2003) J Neurochem. 84: 382-391.6. Bai L., Zhang X., and Ghishan F.K. (2003) Am. J. Physiol. Gastrointest. Liver Physiol. 284: G808-814.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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