Product Type: Inhibitor
CAS No.: 274901-16-5
MolecularFormula: C17H25N3O2
Molecular Weight: 303,4
Source: Synthetic
Purity: >98% (HPLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (45 mg/ml); or DMF (20 mg/ml); or ethanol (20 mg/ml)
Appearance: White powder
PubChem CID: 11077541
Scientific Background: Vildagliptin is a potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1) (1). Delaying the degradation of GLP-1 extends the action of insulin and suppresses the release of glucagon which results in reduction in elevated blood glucose levels (hyperglycemia) (2). It is a clinically useful antidiabetic agent.
References: 1. B Balas et al., (2007) J. Clin. Endocrinol. Metab. 92:1249.2. B Ahren et al., (2004) J. Clin. Endocrinol. Metab. 89:2078.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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