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Biological Activity: Inhibits two ABC transporters, ABCG2/BCRP and ABCB1/Pgp, with IC50 values of 1.4 and 3.0 µM, respectively.
CAS Number: 879085-55-9
Description: Vismodegib (GDC-0449) is a potent hedgehog (Hh) signaling pathway inhibitor.
Format: A crystalline solid
Purity: ≥99% by HPLC
Solubility: Soluble in DMSO at 200 mg/ml; soluble in ethanol at 10 mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Von Hoff, D.D., et al. N. Engl. J. Med. 361: 1164-1172 (2009).
2. Zhang, Y., et al. Neoplasia 11: 96-101 (2009).
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