VL422, CAS 2765519-47-7

Formulation: A solution in ethanol

Formal Name: octanedioic acid, 1,1′-[2-[[[[3-(diethylamino)propoxy]carbonyl]oxy]methyl]-1,3-propanediyl] 8,8′-bis(1-octylnonyl) ester

Purity: ≥95%

Formula Markup: C62H117NO11

Formula Weight: 1052,6

Shelf life (days): 730

CAS Number: 2765519-47-7

Notes: VL422 is an ionizable cationic lipid.{49830} It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for gene editing in vitro and in vivo. LNPs containing VL422 and encapsulating Cas9 mRNA and sgRNA targeting the gene encoding angiopoietin-related protein 3 (ANGPTL3), a protein whose loss-of-function decreases LDL, HDL, and cholesterol plasma levels, induce a deletion in a premature stop codon in ANGPTL3 in the livers of cynomolgus monkeys.

• SKU: CAY39874-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39874-5
• Package Unit: 5 mg
• Quantity Unit: STK