Formulation: A solid
Formal Name: (6S,9S,12S,15S,18S,21S,27S,30S,33S,36S,39S)-36-((1H-indol-3-yl)methyl)-1,6-diamino-30-(3-amino-3-oxopropyl)-21,27-bis(4-aminobutyl)-15,18-dibenzyl-39-carbamoyl-12,33-bis(4-hydroxybenzyl)-1-imino-9-isopropyl-7,10,13,16,19,22,25,28,31,34,37-undecaoxo-2,8,11,14,17,20,23,26,29,32,35,38-dodecaazadotetracontan-42-oic acid, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C82H112N20O17 • XCF3COOH
Formula Weight: 1649,9
Shelf life (days): 1460
Notes: VnP-16 is a synthetic peptide fragment that corresponds to amino acids 270-281 of vitronectin, a multifunctional glycoprotein with roles in cell attachment, migration, and spreading.{51432} It induces attachment and cell spreading of isolated human osteogenic cells, an effect that can be reversed by siRNA knockdown of β1 integrin, when applied to cell plates at a concentration of 9.1 µg/cm2. VnP-16 induces osteogenesis of human skin-derived mesenchymal precursors and MC3T3-E1 mouse calvarial osteoblast precursors. In vivo, VnP-16 decreases IL-1α-induced bone loss and decreases the number of calvarial osteoclasts in mice. It also increases bone mineral density and decreases trabecular bone loss in a mouse model of ovariectomy-induced bone loss.
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