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Applications: Screen and validate antibodies against VSIG4 for drug discovery and research.Perform binding assays to screen for potential VSIG4 ligands
Background: VSIG4, also known as V-set and immunoglobulin domain containing 4, is an immunoglobulin of the B7 family of immune regulatory proteins. VSIG4 contributes to immune homeostasis by multiple mechanisms. It is a receptor for the complement component 3 fragment C3b and iC3b, where binding triggers receptor internalization and promotes inflammation. While most of the B7 homologues are expressed at low levels in resting cells, VSIG4 is abundantly expressed in non-active peripheral tissues macrophages and downregulated when cells become activated and is hardly found in lymphoid tissue macrophages. VSIG4 has been identified as an inhibitor of T cell responses as effective as PD-L1 (programmed death-ligand 1), inhibiting T cell proliferation and contributing to cancer progression. Similarly, to PD-L1, VSIG4 can be considered an immune checkpoint and is an attractive target in cancer therapy.
Description: VSIG4 CHO Cell Line is a clonal CHO cell line stably expressing full-length human VSIG4 (V-set and immunoglobulin domain containing 4) (NM_007268.3). Surface expression of VSIG4 was confirmed by flow cytometry. This stable clonal cell line was selected for high levels of VSIG4 expression compared to the parental CHO-K1 cell line.
Host Cell Line: CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage. Contact technical support at support@bpsbioscience.com if the cells are not frozen in dry ice upon arrival.
Supplied As: Each vial contains >1 x 106 cells in 1 ml of Cell Freezing Medium (BPS Bioscience #79796)
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-1
References: Vogt L., et al., 2006 J Clin Invest. 116(10): 2817-26.Liu B., et al., 2023 Cancer Lett. 553: 215996.
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