VU-29, CAS 890764-36-0

Description: VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM).

CAS Number: 890764-36-0

Formula: C22H16N4O3

Molecular Weight: 384,39

References: Chen Y , Nong Y , Goudet C , et al. Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.[J]. Molecular Pharmacology, 2007, 71(5):1389-1398.

• SKU: TGMT23515-5mg
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: T23515-5mg
• Package Unit: 5 mg
• Quantity Unit: STK