Target: WDR45.
Conjugate: FITC.
Product Type: Polyclonal.
Immunogen: Synthetic peptide from the C-terminal of Human WIPI4 (aa. 312-322).
Swiss-Prot: Q9Y484.
Purification: Peptide Affinity Purified.
Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide.
Concentration: 1 mg/ml.
Specificity: Detects ~40 kDa.
Tissue Specificity: Ubiquitously expressed, with high expression in skeletal muscle and heart. Weakly expressed in liver and placenta. Expression is down-regulated in pancreatic and in kidney tumors.
Scientific Background: WIPI-4 is a 360 amino acid protein containing three WD repeats. Existing as three alternatively spliced isoforms, WIPI-4 is ubiquitously expressed but found at highest levels in heart and skeletal muscle. WD repeat proteins are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Diseases associated with this gene include neurodegeneration with brain iron accululation 5 and 4.
References: 1. http://www.genecards.org/cgi-bin/carddisp.pl?gene=WDR45 2. Strausberg R.L., et al. (2002) Proc Natl Acad Sci U S A. 99(26): 16899–16903. 3. Haack T.B., et al. (2012) Am J Hum Genet. 91(6): 1144–1149.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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