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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: Wee1 is a tyrosine kinase that is overexpressed in many cancer types such as luminal and HER2-positive breast cancer subtypes, hepatocellular carcinomas, and glioblastomas. Wee1 plays a crucial role in regulating the cell division cycle through phosphorylation of CDKs. Inhibiting Wee1 has been shown to prevent the cells from repairing DNA damage due to unchecked replication, suggesting possible combination therapeutics of the DNA damaging reagents and Wee1 inhibitors.
Description: The Wee1 Assay Kit is designed to measure Wee1 activity for screening and profiling applications using Kinase-Glo® Kinase Assay as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Supplied As: The Wee1 Assay Kit comes in a convenient 96-well format, with enough purified recombinant Wee1 enzyme, Wee1 Substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
Biosafety Level: Not applicable (BSL-1)
References: 1. Parker, L., et al., Science 1992; 257(5078):1955.
2. Lundgreen, K., et al., Cell 1991 Mar; 64(6):1111-1122.
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