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Background: Wnt-C59 prevents palmitoylation of Wnt proteins by Porcupine (a membrane-bound O-acyltransferase), thereby blocking Wnt protein secretion and activity, similar to Wnt inhibitors IWP-2, IWP-3 and IWP-4. But Wnt-C59 is more potent and selective, and has better chemical/physical properties, and is more suitable for in vitro/in vivo studies.
CAS Number: 1243243-89-1
Description: Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.
Solubility: Soluble in DMSO
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: Porcupine
Biosafety Level: Not applicable (BSL-1)
References: Proffitt KD, et al. Cancer Res. 2013 Jan 15;73(2):502-7.
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