XIE62-1004, CAS 2421146-32-7

Formulation: A solid

Formal Name: 2-[[[3,4-bis(phenylmethoxy)phenyl]methyl]amino]-ethanol, monohydrochloride

Purity: ≥98%

Formula Markup: C23H25NO3 • HCl

Formula Weight: 399,9

Shelf life (days): 1460

CAS Number: 2421146-32-7

Notes: XIE62-1004 is an inducer of autophagy.{51665} It increases the number of p62 aggregates, as well as the number of autophagosomes and autolysosomes, in wild-type HeLa cervical cancer cells, but not in HeLa cells deficient in the gene encoding p62, SQSTM1, when used at a concentration of 10 µM. XIE62-1004 induces autophagic flux and the conversion of LC3 autophagy marker I (LC3-I) to LC3-II in HeLa cells. It increases the degradation of mutant huntingtin (mHTTQ103) protein expressed in HeLa cells.

• SKU: CAY40446-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40446-25
• Package Unit: 25 mg
• Quantity Unit: STK