YCH1899

Formulation: A solid

Formal Name: 4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one

Purity: ≥98%

Formula Markup: C25H18BrFN6O3

Formula Weight: 549,4

Shelf life (days): 1095

Notes: YCH1899 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 50s = 1-14.1 nM). YCH1899 inhibits the proliferation of Capan-1 cells (IC50 = 0.1 nM), as well as Capan-1 cells resistant to the PARP inhibitors talazoparib (BMN 673; Item No. 19782) or olaparib (Item No. 10621; IC50s = 1.13 and 0.89 nM, respectively). It inhibits the proliferation of BRCA1 mutant HCC1937 breast cancer cells (IC50 = 4.54 nM). In vivo, YCH1899 (12.5 and 25 mg/kg) reduces tumor growth in an olaparib-resistant MDA-MB-436 breast cancer mouse xenograft model.

• SKU: CAY39737-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39737-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK