Product Type: Inhibitor
CAS No.: 409086-68-6
MolecularFormula: C20H20ClN3OS2
Molecular Weight: 417.97
Source: Synthetic
Purity: >98% (HPLC)
Solubility: Soluble in warm water (2 mg/ml)
Appearance: Orange red solid
Scientific Background: YM-01 is an allosteric Hsp70 inhibitor. It binds with in Hsp70's nucleotide binding domain, adjacent to ATP/ADP binding pocket. It inhibits J-stimulated ATP turnover rate. It blocks Hsc70-bag1 interaction both in vitro and in vivo and enhances binding of Hsp70 to misfolded proteins. It reduces tau levels in tau-overexpressed HeLa cells, endogenous tau in neuroblastoma cells, and endogenous tau in primary neuron from rTg4510 mice, with EC50's of low micromolar. It recovers long-term potentiation deficits in brain slices from rTg4510 mice. It also has anti-cancer activity, with an EC50 value of low micromolar against several cancer cell lines. It destabilizes oncoproteins in cells, including Akt and Raf-1. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
References: 1. Wang et al., 2013 Nature Chem. Biol. 9: 112-118.2. Abisambra et al., 2013 Biol. Psychiatry, 74: 367-374.3. Koren et al. PLoS One 7:e35566.4. Morishima et al. 2011 Biochemistry. 50: 7146.5. Davis et al. 2012 J. Immunol. 189: 4488.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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