Product Type: Inhibitor
CAS No.: 812647-88-4
MolecularFormula: C19H17N3OS2
Molecular Weight: 367.49
Source: Synthetic
Purity: >99% (HPLC)
Solubility: Soluble in DMSO
Appearance: Yellow-orange solid
Scientific Background: YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn′t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
References: 1. Miyata, Y. et al. 2013 ACS Chemical Neuroscience Jun 19;4(6):930-9. doi: 10.1021/cn300210g
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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