Zanubrutinib, CAS 1691249-45-2

Formulation: A solid

Formal Name: (7S)-4,5,6,7-tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxamide

Purity: ≥98%

Formula Markup: C27H29N5O3

Formula Weight: 471,6

Shelf life (days): 1460

CAS Number: 1691249-45-2

Notes: Zanubrutinib is a potent and covalent inhibitor of Bruton's tyrosine kinase (BTK; IC50 = 0.3 nM).{52108} It is selective for BTK over a panel of 304 kinases at 1 μM but does inhibit EGFR, Tec, Blk, BMX, HER4, and TXK (IC50s = 0.62-33 nM). Zanubrutinib inhibits phosphorylation of BTK at Y233 (IC50 = 1.8 nM) in Ramos cells and reduces viability of REC-1 cells (IC50 = 0.36 nM). In vivo, zanubrutinib (2.5 and 7.5 mg/kg) reduces tumor volume in an OCI-LY10 diffuse large B cell lymphoma (DLBCL) mouse xenograft model.

• SKU: CAY28924-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 28924-1
• Package Unit: 1 mg
• Quantity Unit: STK