Clone Name: ZAP70/3921R
Application Note: IHC-P: 1-2 μg/ml. ELISA: 2-4 μg/ml (for coating). *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 70
Form: Liquid
Buffer (with preservative): 1mM PBS, 0.05% BSA, 0.05% Sodium azide.
Concentration: 200 μg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot ID: P43403
Antigen Species: Human
Immunogen: Recombinant fragment (around aa 247-382) ofhuman ZAP70 protein
Purification: Protein A/G purified
Conjugation: Unconjugated
Full Name: zeta chain of T cell receptor associated protein kinase 70
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